TS-Si is dedicated to the acceptance, medical treatment, and legal protection of individuals correcting the misalignment of their brains and their anatomical sex, while supporting their transition into society as hormonally reconstituted and surgically corrected citizens.
| Male to Female Post-Op Pregnant: Stem Cells Used to Clone Uterus |
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| Living - One Fine Day | |||
| TS-Si News Service | |||
| Tuesday, 31 March 2009 22:30 | |||
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Scientists and doctors have used stem cells have been used to grow new kidneys to replace failing ones, new hearts to take the place of dying ones, and sexual genitalia when cancer has taken the old ones. Ms. Smith, a woman born with Harry Benjamin Syndrome (Obsolete HBS or “classic transsexuality") is the recipient of both ovaries and uterus. After years of struggling with her sexual identity before being diagnosed with HBS, Smith underwent Sex Reassignment Surgery (SRS) five years ago in Scottsdale, Arizona. Since then, she has been legally female, a fact her Driver’s License, U. S. Passport, and California birth certificate so indicate. But she was unable to have children until now. Smith defended her right to have a baby, saying that she “has a right to a biological child.” In an exclusive interview with Oprah Winfrey, Smith said that her lifelong desire to have children motivated her to have working female reproductive organs [N2] implanted in her body.
Doctors at John Hopkins said that
Smith’s obstetrician indicated that both mother and fetus are doing well and he anticipates a normal birth in the last week in December. Doctors at John Hopkins, working with researchers at the California Institute of Technology and John Varley University, developed the technology that makes the implantation of new organs possible. Stem cells thrive in segments of well-vascularized tissue temporarily removed from laboratory animals. Once the cells have nestled into the tissue’s nooks and crannies, the so-called “bioscaffold” can then be seamlessly reconnected to the animal’s circulatory system. The new technique neatly sidesteps a fundamental stumbling block in tissue engineering: the inability to generate solid organs from stem cells in the absence of a reliable supply of blood to the interior of the developing structure. Stem cells in the tissue are induced to become internal, living factory of healthy, specialized cells churning out proteins missing in people with conditions such as hemophilia or diabetes and are now used grow entire transplantable organs such as the uterus and ovaries implanted in Smith. After Smith went public [N5], she has received death threats, and thousands of hateful comments, many of which still litter the Internet. She continues to receive anonymous hate mail. Smith and her husband have since retreated to a quiet life in the Shenandoah Valley in Virginia and are rarely seen now in public, keeping their blinds drawn and monitoring surveillance cameras that surround their property. Smith says she won’t fear rule their lives and she feels they are a traditional family.
Notes[N1] Michelle Valentina Smith née Michael Valentine Smith.
[N2] Ovaries and uterus. [N3] Michelle V. Smith on Oprah. [N4] CBS Nightly News. [N5] Oprah Winfrey, Ellen, Two and a Half Men, CSI, Survivor, Late Late Show with Craig Ferguson, et al. [N6] Smith, interview in L’Osservatore Romano. FundingThe initial research was supported by grants from the National Institutes of Health (NIH) and the National Institute of Biomedical Imaging and Bioengineering (NIOBIOB).
Contributors Hopkins collaborators on the research include postdoctoral scholars Thomas Paul Jefferson, MD, Edward McChang, MD, Hugh Bonillas, MD, and L. J. Thompson, PhD Neurobiological Engineering, John Varley University, Farside Station, RM.
CitationEngineering of reproductive tissues using autologous microcirculatory beds as vascularized bioscaffolds for organ construction. Thomas P. Jefferson, Edward McChang, Robert G. Bonillas, L. J. Thompson. TANSTAAFL 2048; 23(3): 01042009. doi: 10.1096/apr.01.fo.ols.08-114868.
Abstract Classic tissue engineering paradigms are limited by the incorporation of a functional vasculature and a reliable means for reimplantation into the host circulation. We have developed a novel approach to overcome these obstacles using autologous explanted microcirculatory beds (EMBs) as bioscaffolds for engineering complex three-dimensional constructs. Based on this approach, we have successfully cloned ovaries and uterus from the stem cells of a forty year old post-operative woman born transsexual who wished to become pregnant. EMBs consisting of an afferent artery, capillary beds, efferent vein, and surrounding parenchymal tissue are explanted and maintained for 24 h ex vivo in a bioreactor that preserves EMB viability and function. Given the rapidly advancing field of stem cell biology, EMBs were subsequently seeded with three distinct stem cell populations, multipotent adult progenitor cells (MAPCs), and bone marrow and adipose tissue-derived mesenchymal stem cells (MSCs). We demonstrate MAPCs, as well as MSCs, are able to egress from the microcirculation into the parenchymal space, forming proliferative clusters. Likewise, human adipose tissue-derived MSCs were also found to egress from the vasculature and seed into the EMBs, allowing viable natural fertilization of the subsequent ova. We further demonstrate that MSCs can be transfected to express a luciferase protein and continue to remain viable and maintain luciferase expression in vivo. By using the vascular network of EMBs, EMBs can be perfused ex vivo and seeded with stem cells, differentiating direction into neo-organs or transfected to replace failing organs and deficient proteins.
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| Last Updated on Saturday, 28 July 2012 18:59 |
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Comments
(On a personal note, I have finally with the help of my doctor found a diet (South Beach) that is working - with the side effect of blood sugar now being under control for the first time in over ten years, and I am now only 66 pounds (and counting down) away from my surgery letter! The weird thing is that for me, South Beach diet isn't a big change from my previous eating habits and regular potatoes - adding greek yogurt, beans and nuts, and subtracting most refined wheat products, and severely limiting pasta, rice, peas (yes, this description is oversimplified) . I can fill my chocolate craving with a breakfast blender smoothie composed of Soy Slender chocolate soymilk, Chobani greek yogurt, a squirt of Stop&Shop diet chocolate syrup and a half tsp of instant coffee and six ice cubes, or with an occasional dessert of 60 cal sugar-free Jello Dark chocolate cup with a sprinkling of almonds (reminding me of a Hershey bar with almonds . . . ) For the first time I can see the light at the end of the tunnel, and that is not an "April Fool."
Who knows, it may arrive again this year. We will have to wait and see.
Pamela
Please read the piece and other comments very carefully.
Have you FAILED to read the other comments that this was an APRIL FOOLS JOKE? That's NOT "being mean" to you, it is poking at those that think being a woman means having to bear children in their own womb. I AM a woman, I HAVE been female in brain since birth, thanks to modern surgery, I now have a body to match my brain. That's quite a step.
Please read the piece and other comments very carefully.
How would you like it if someone wrote your dream as a `satire' peice, only to find it be a joke... You see it you get all exicted, you start ot tell poeple... then :( as always, your life is a joke. Thanks a lot, keep up the hurtful writing.
This post should really be taken down... I'm sure I'm not the only one who wants children and was fooled by this trash.
Seriously: TO the writers: This is mean, and hateful. Please take it down. Our dreams are not just an `April Fools' joke for you to laugh at.
This was my first and last time to this site. Let this comment stand as a warning to any women out there: Dont read this, you'll only get hurt.
Once again, someone wanders into the comment thread for a satirical piece and reacts to satire as a hateful personal attack. Lighten up! We all need to laugh at ourselves once in a while.
Even more, the satire was directed at post-ops like us. And I am not offended.
It isw also in peer reviewed journals and in Fang Fu Ruan's book chapter 7.
I see that you are still as gullible as ever.
Boy, Id REALLY believe anything started in China and reviewed in Fang Fu's book. It's "SURE" to be true.
Would you like to buy a nice bridge in the Gobi Desert?
I repeat my statement: "To date there is no documented case of effective ovarian and/or uterine transplantation in any person born transsexual."
If you believe there is such documentation please provide the reference(s).
The problem is not a lack of appropriate surgical techniques and facilities. In fact, both general plastic surgery and such precise surgical techniques as reimplantation of severed fingers are very advanced in China. Dr. Xia, in the Plastic Surgery Department of the Third Hospital of Beijing Medical University, has successfully operated simultaneously on a male-to-female transsexual and a female-to-male transsexual with mutual exchange and transplantation of ovaries and testicles; this surgery took nineteen hours
1st page is free.
journals.lww.com/.../...
had the ovaries functioning for a year at publication and they feminized her body.
I assume they ovulated. I do not know how long after the publication that the ovaries kept functioning. If I could have functioning ovaries for a year I would go for it. I do realize that it is unusual to have ovaries for the purpose of feminization of one's body.
It is also not a research paper so there is really no need to replicate it. It is just a report on a procedure that they did. Longitudinal reports of reports on transsexual surgeries and so on are not that informative since so many transsexuals go on wit their lives.
But wanting something to be true and effective does not make it so. You have chosen to bring up a report from 1994 that caused some interest at the time, but has failed to gain purchase in the medical community. There are several reasons for this.
(1) The initial report of the work by Xia et al was mentioned in lectures by Dr. Fang-fu Ruan, a physician and medical historian who specializes in sexology, erotica, and oriental hstory.
(2) A 1994 note appeared in the Correspondence and Brief Communication section of the journal Plastic & Reconstructive Surgery. The author was a third party who used the forum to alert colleagues to the existence of the initial case report.
(3) The Chinese study did in fact contain erroneous science. Even if we assume the transplant attempts were actually made, the methodological errors are plain. They included avoidance of the larger endocrine context, undocumented pre-surgical analysis of adrenal activity, inadequate serum baselines, episodic tracking of immunosuppresan t variations, and related matters.
(4) Whatever the reasons, there is no report that a longitudinal followup of the four patients was conducted. The reasons could be quite legitimate but not doing so hampers assessment of outcomes -- especially the significance of the reported rejection events and detailed information on function and survival.
(5) There are no reports that the surgical procedure under discussion has been replicated. Thus, comparative studies are unavailable.
(6) The report was largely discounted by professionals, but gained public notice when it was circulated among well-meaning but over-enthusiast ic laypeople who overinterpreted the implications.
Cross-sexual transplantation of human gonads in transsexuals. Hage, J. Joris M.D., Ph.D. Plastic & Reconstructive Surgery 1994; 94(3): 564-565. PMID 8047614
journals.lww.com/.../...
I have provided you evidence that in fact there
is documented case in Plas Rec Surg. that the case DID occur and that the authors did write they had SUCCESSFULLY done the ovarian transplant operations. Furthermore, the success was not only in the transplantation but the EVIDENCE provided in the hormonal changes of the FUNCTION of the ovaries for at least one year. Further they state that the patients feminization is based upon the ovarian tranbsplants. Your statement is invalidated. You have no evidence that because Dr. Fang Fu Ruan reported it that his reporting had any adverse effects on the way the report wa received. (PS-he was not the first to report on it). Next, it does not matter that the Chinese article was not translated but that inatead a summary was published in English. The purpose was to summarize the findings-not to reprint or translate an article that was in Chinese. Just because a summary does not have all the details of this operation does not mean that there are errors in the summary. A video of actual footage of the procedure was presented at International Congress on Gender, Cross Dressing and Sex Issues Feb. 24-26 in Van Nuys, CA sponsored by Cal State Northridge Center for Sex Research. Dr. Xia presented there and you can still get the proceedings and a video. Ovarian transplants were still functioning. The only criticism in the round touble discussion is that it is not worth transplanting and using anti-refection drugs when hormonal replacement can do the job.
Also, I did in fact read the source article.
I do not resist your claims lightly. It is just that to do this at all it is important to do it well, to be thorough, and proliferate the results.
I do a lot of work in bioscience and medical research. This piece does not pass muster. I wish it did, and perhaps the successor work will improve the situation, but we aren't there yet.
ncbi.nlm.nih.gov/.../7809245
If you want more details there is a publication in Chinese. But again this is just a clinical report not a research study. But the transplantation , the lack of rejection for at least one year with the immunosupressiv es and the feminization DID occur. It does not say that what they did should even be researched or tried again. It is just a medical report and documented in print and in med video.
In any case, I think this thread has outlived any usefulness it ever had, given that the comments have wandered away from the original satirical article.
The readers of this forum can just check the references themselves. PS- I did indicate that I would like to have functioning ovaries
"The reported surgical event(s) have not been replicated. From a medical research perspective, the work is not fully documented without replication (among other factors)."
Now you claim more exposure for it BUT with no further replication of the operation.
Sad; Believe what you want; the story lacks credibility.
providing. It is not s story. It is a credible medical report in credible reputable journals by credible reputable physicians. I will believe them over you.
It is sad that you have not presented facts but just a blatant dismissal of procedures that have been documented in med journals and conferences.
I dispute your "facts" and what you call reputable.
Now go off and have a good time;
Bless Your Heart.
believe what you want; The more you screech the more I doubt its true;
But you have a good day now you hear ?
will just need to read it and decide.
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