It is strange, but necessary, to state the obvious: people born with transsexuality are human beings.

Most people experience their innate gender and physical sex in a unified way. They come to be regarded as a man or a woman. For others, this basic process is interrupted and they are born TS.

For TS individuals, gender and sex are misaligned at birth. Their inner gender reality and external anatomy do not match. This is a random and rare event that often leads to tragic endings.

The birth condition is a fact. No TS person chooses their innate gender — that is a condition of every human’s birth. The misalignment of sex is the only issue.

As far as is known, TS babies are born into every culture, without regard to ethnic origin, race, religion, income or social class, or any other arbitrary social classification.

TS persons are not generally accepted by their families and society. Too many times, they face a lifetime of social bias, uninformed medical treatment, and hostility from public authorities.

In many instances, they are deprived of equal protections under the law and too often perceived as dangerous to the public order by uninformed social conservatives.

Left untreated, TS persons die at alarming rates from careless living, suicide, and murder. Those who do not die a physical death face the likelihood of a death-in-life with severe emotional and mental disturbances.

Some people with this birth condition find help, developing the necessary self-awareness and resources to take action. They transition into society and resolve the misalignment of their birth condition.

Despite daunting obstacles, TS persons can make the changes necessary to bring their physical sex into alignment and become whole.

There is a developing community of scientists, doctors, helping professionals, and ordinary people of good will who realize that something must be done. They understand both the torment and wasted human potential of TS people.

Those who survived transition have learned many things they can pass back to society at large. They have experienced the best and the worst of the turmoil surrounding issues of gender, sex, and equality.

Much remains to be done and we need your help.

Let’s get started on making a change!

The TS-Si Research Service consolidates information on research initiatives and findings relevant to the misalignment of brains and anatomical sex. The service tracks key scientific and medical developments from early consideration of research opportunities and published findings through practical application in clinical settings.

Researchers and students from qualifying institutions regularly receive special emailings from TS-Si that consist of abstracts and other materials that support their interest areas.

The TS-Si News Service is a collaborative effort by TS-Si.org editors, contributors, and corresponding institutions. Sources can include the cited individuals and organizations, as well as TS-Si.org staff contributions. Articles and news reports do not necessarily convey official positions of TS-Si, its partners, or affiliates. We welcome your comments. Use the form below to leave a public comment or send private correspondence via the TS-Si Contact Page. We will not divulge any personal details or place you on a mailing list without your permission.


TS-Si is dedicated to the acceptance, medical treatment, and legal protection of individuals correcting the misalignment of their brains and their anatomical sex, while supporting their transition into society as hormonally reconstituted and surgically corrected citizens.

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