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| Molecular Scaffold Guides Connections Between Brain Cells |
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| SciMed - Neuroscience | |||
| TS-Si News Service | |||
| Friday, 23 May 2008 17:00 | |||
Cold Spring Harbor, NY, USA. Brain cells known as neurons process information by joining into complex networks, transmitting signals to each other across junctions called synapses. A research team has identified molecules guiding this highly specific neuronal targeting in the developing brains of mice. But “neurons don’t just connect to other neurons,” emphasizes Z. Josh Huang, Ph.D. He says that “in a lot of cases, they connect to very specific partners, at particular spots.” Dr. Z Josh Huang, Ph.D., a professor at Cold Spring Harbor Laboratory (CSHL) and his team have shown that in some cases, these molecular guides — non-signaling brain cells known as glia — form a kind of scaffold. This scaffold, in turn, directs the growth of nerve fibers and their connections between specific types of neurons.
Bergmann Glia and the Recognition Molecule CHL1 Organize GABAergic Axons and Direct Innervation of Purkinje Cell Dendrites. Ango F, Wu C, Van der Want JJ, Wu P, Schachner M, et al. PLoS Biology 6(4) e103 doi: 10.1371 / journal.pbio.0060103 [ Download PDF ] The researchers report their findings on the forging of neural networks in PLoS Biology. As they learn through research like this how the brain develops its complex wiring, the scientists hope they can clarify what goes wrong in certain birth conditions and disorders like autism.
The Cerebellum’s Organized Architecture
Distinctive wiring patterns are unmistakable in the cerebellum, a brain region best known for controlling movement, in both mice and people. Compared to regions involved in more sophisticated functions like vision and thought, “the cerebellum is an easier place to start, because of its very organized architecture,” Dr. Huang says, although he notes that other parts of the brain have their own specific wiring patterns.
Central to the wiring architecture of the cerebellum are so-called Purkinje cells, a type of neuron that deploys a bushy array of fibers called dendrites that extend through layers of cerebellar territory. The dendrites gather signals from many other neurons in the cerebellum and send signals to other parts of the body.
 Microcircuitry of the cerebellum
Excitatory synapses are denoted by (+) and inhibitory synapses by (-).
MF: Mossy fiber.
DCN: Deep cerebellar nuclei.
IO: Inferior olive.
CF: Climbing fiber.
GC: Granule cell.
PF: Parallel fiber.
PC: Purkinje cell.
GgC: Golgi cell.
SC: Stellate cell.
BC: Basket cell.
The complex wiring pattern emerges during early brain growth, when individual neurons migrate from their places of origin in other regions and emit filaments (axons) that connect to particular parts of other neurons, such as the dendrites.
Dr. Huang likens this process to the address on a letter that brings it from another country directly to your door by specifying the country, state, city, street, and house number. He and other brain researchers have learned much about the higher levels of this addressing scheme, identifying, for instance, chemical signals that guide axons to the right section of the brain, and different signals that lead them to the appropriate layer within that section.
How Neurons Form Synapses
Only recently, however, have Dr. Huang and his colleagues traced the chemical signals leading neurons to form synapses with specific parts of other neurons.
 Such sub-cellular specificity is critical to ensure the precision and reliability of communication among neurons. Synapses are the tiny gaps across which nerve cells exchange signals, conveyed by chemicals called neurotransmitters. A few years ago, Dr. Huang’s team established that a protein from the immunoglobulin family directs one group of cerebellar neurons to connect with a specific part of Purkinje cells. Immunoglobulin proteins are best known for acting as antibodies in the immune system, where they take on myriad forms to attack new invaders. Here, however, they are observed to be involved in the wiring of the brain.
“The striking feature is that there is a lot of capacity for variety” in immunoglobulin molecules, Dr. Huang explains. In the nervous system, their versatility may help them guide cells to form synapses with specific partners.
Intriguingly, Dr. Huang adds, immunoglobulins have been implicated in neural developmental disorders, such as autism. “There is good evidence that these disorders involve miswiring of the nervous system,” Dr. Huang says, which may reflect a problem with immunoglobulin-guided synapse formation.
A Guiding Scaffold Made of Glial Cells
Dr. Huang’s team traced the sub-cellular targeting of a different set of cerebellar neurons called stellate cells, which make numerous connections to the dendritic “bush” emanating from clumps of Purkinje cells. Unlike the cells they had studied previously, however, these neurons need help to form synapses. The researchers developed sophisticated techniques to label different cell types with chemical markers, and found that non-signaling cells called glia act as a scaffold, guiding the growing axons of the stellate cells and determining where they form synapses to the Purkinje cells.
In this role, the glia act something like “matchmakers” to bring the stellate and Purkinje cells together. But Dr. Huang notes that the scaffold of glia interspersed among the neurons allows each stellate cell to make contact to many different Purkinje cells. A direct attraction between stellate and Purkinje cells, he suggests, might lead two cells two pair up exclusively.
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The TS-Si News Service is a collaboration of TS-Si staff, contributors, and corresponding institutions. Contents do not necessarily convey official positions of TS-Si, its partners, or affiliates