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TS-Si News Service
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Wednesday, 25 June 2008
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Washington, DC, USA. General anesthesia puts patients into unconscious sleep so they do not feel surgical pain, but researchers say it can increase their discomfort once they wake up.
The findings provide scientific confirmation for an increasing number of anecdotal observations in clinics.
In the Proceedings of the National Academy of Sciences (PNAS), scientists report that "noxious" anesthesia drugs — which includes most of these general anesthetics - activate and then sensitize specific receptors on neurons in the peripheral nervous system. These are the sensory nerves in the inflammation and pain pathway that are not affected by general anesthesia drugs that target the central nervous system – the brain and the spinal cord.
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. José A. Matta, Paul M. Cornett, Rosa L. Miyares, Ken Abe, Niaz Sahibzada, and Gerard P. Ahern. PNAS 2008 105(25) 8784-8789. 10.1073 / pnas.0711038105 [ Supporting Info PDF ]
"The choice of anesthetic appears to be an important determinant of post-operative pain," according to Gerard Ahern, Ph.D., an assistant professor in the GUMC Department of Pharmacology. "We hope these findings are ultimately helpful in providing more comfort to patients."
Ahern says that general anesthetics have long been known to cause irritation at the infusion site or in the airways when inhaled.
And investigators have also known that while they suppress the central nervous system, they can activate so called "pain-sensing" or nociceptive nerve cells on the peripher
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TS-Si News Service
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Monday, 23 June 2008
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Edmunton, Alberta, Canada. Does emotional wisdom come with age? Researchers identified brain patterns that help healthy people over the age of 60 regulate and control emotion better than younger counterparts. Two brain regions increased activity when participants viewed standardized pictures of emotionally challenging situations.
Effects of aging on functional connectivity of the amygdala during negative evaluation: A network analysis of fMRI data. Peggy St. Jacques, Florin Dolcos, Roberto Cabeza. Neurobiolology of Aging ePub 2 May 2008. doi: 10.1016 / j.neurobiolaging.2008.03.012. PII: S0197-4580(08)00105-X.
The study, published in Neurobiology of Aging, was performed under the co-ordination of Dr. Roberto Cabeza and in |
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Sharon Gaughan
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Friday, 20 June 2008
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DSM-IV is the desktop reference used most often by physicians and other caregivers for diagnostics, both in the United States and around the world.
The APA named the Work Groups and membership for next revision, DSM-V, mandating an early draft for comment in 2009 and completion scheduled for May 2012.
The APA announcement stimulated wide interest in the professional, patient, and activist communities. TS-Si.org has expanded its coverage of this important development with a variety of articles that touch on the DSM-V deliberations.
Reactions and suggestions from our readers are always welcome. You can see current comments from our readers in the TS-Si.org Comments Section.
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Annotated list originally published 29 May 2008, with periodic updates.
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TS-Si News Service
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Monday, 09 June 2008
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Malaga, Andalucia, Spain. There has been relatively little systematic study of the effects of long-term cross-sex hormone therapy in male-to-female (M2F) and female-to-male (F2M) transsexuals [cf. sidebar]. Now, this is beginning to change. A research team from Hospital Regional Universitario Carlos Haya [N1] studied changes in the serum uric acid (urate) levels. Uric acid, an organic compound, is produced in large quantities by the normal human metabolism.
Ordinarily, people can have elevated levels of uric acid for variety of hereditary or dietary reasons. Any changes in may be an independent mortality factor of Coronary Heart Disease (CHD), cytokines, and various inflammatory markers. Cytokines are a general category of signalling proteins and glycoproteins, critical to the functioning of both innate and adaptive immune responses. Cellular communication depends on them , along with hormones and neurotransmitters.
Effect of Long-Term Administration of Cross-Sex Hormone Therapy on Serum and Urinary Uric Acid in Transsexual Persons. R. Yahyaoui, I. Esteva, J. J. Haro-Mora, M. C. Almaraz, S. Morcillo, G. Rojo-Martínez, J. Martínez, J. M. Gómez-
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Springfield, VA, USA. Society (the women and men around us) has always been more comfortable if its members fall within certain known, established patterns: this is how we dress, this is what we say, this is... |
Washington, DC, USA. Science shows that the human brain and central nervous system form before the remaining portions of our overall body plan. This is a central insight and the province of developmental biology, particularly embryology, which deals with the development of organs and other anatomical structures... |
Edmunton, Alberta, Canada. Does emotional wisdom come with age? Researchers identified brain patterns that help healthy people over the age of 60 regulate and control emotion better than younger counterparts. Two brain regions increased activity when... |
Washington, DC, USA. Criticism of the Washington state Democratic Party for an attack ad that linked an Italian-American politician to fictional organized crime. The Pennsylvania Senate ponders expansion of bathroom access to people with bowel disorders. North Carolina's motor vehicle department embarrassed by a sample license plate on its... |
Washington, DC, USA. As fuel and energy costs continue to soar to record highs, a growing number of states are offering more of their public employees compressed workweeks to hold down states’ energy spending and give long-distance commuters some relief from paying high gas prices.
Utah Gov. Jon Huntsman... |
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TS-Si News Service
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Wednesday, 14 May 2008
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Friday, 02 May 2008
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Friday, 02 May 2008
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Sunday, 18 May 2008
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Thursday, 08 May 2008
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Monday, 05 May 2008
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Friday, 21 March 2008
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Friday, 14 March 2008
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TS-Si News Service
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Friday, 14 March 2008
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Sharon Gaughan
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Monday, 19 May 2008
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TS-Si News Service
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Sunday, 11 May 2008
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Friday, 25 April 2008
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Wednesday, 07 May 2008
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Monday, 17 March 2008
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Wednesday, 06 February 2008
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Monday, 02 June 2008
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TS-Si News Service
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Sunday, 01 June 2008
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Dr. Richard Smith
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Thursday, 22 May 2008
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Dr. Richard Smith
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Thursday, 22 May 2008
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Tuesday, 20 May 2008
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So They Say
Despite our mortality, the flesh is the only route we can take to glimpse eternity.
Patrick Califia-Rice
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Subscribe To The TS-Si Insider
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Finding Our Way
Richard Smith, Editor-in-Chief, introduces Cases Journal. Dr. Smith urges all physicians to submit their case reports to the new open access Cases Journal, which publishes case reports from any area of healthcare.
Cases Journal will publish any case report that is understandable, ethical, authentic, and includes all essential information. A more selective companion, the Journal of Medical Case Reports, publishes original and interesting case reports that contribute significantly to medical knowledge. Article submissions are subject to potential publication by either journal. All reports will be entered in a common and open access database.
Time 00:01:35.
TS-Si articles of related interest:
Countdown
US Election: 123 days 6 hrs 30 min
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Research from the 
Copyright © 2005-2008 TS-Si, Inc. • Except where noted, this site is licensed under a Creative Commons Attribution-NoDerivs 2.5 License. • Some rights reserved. • TS-Si is a nonprofit organization dedicated to the acceptance, medical treatment, & legal protection of individuals in the process of correcting the misalignment of their anatomical sex, & supporting their transition into society.