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TS-Si Science Access/Biological Sciences
Brain Before Body: The Spemann-Mangold Experiments
TS-Si News Service
Sunday, 29 June 2008
Washington, DC, USA. Science shows that the human brain and central nervous system form before the remaining portions of our overall body plan. This is a central insight and the province of developmental biology, particularly embryology, which deals with the development of organs and other anatomical structures from the point of conception.
While many questions remain to be answered, scientists have accumulated a great deal of knowledge on the sequence of human development following conception. Prior to the 20th century (and as recently as the 18th), the field of human embryology was in its formative stages. Ideas of preformation were prevalent; that is, the egg or sperm contains the homunculus — a preformed, miniature infant — that gows larger during development.

Uber Induktion von Embryonanlagen durch Implantation artfremder Organisatoren. Spemann, H., and H. Mangold. Roux Arch. f. Entw. mech. 100: 599-638. 1924.

The competing explanation was a proposal by Aristotle some 2,000 years before. Called epigenesis, it supposed that the form of an animal emerges gradually from a relatively formless egg. Instrumentation improved throughout the 19th century, ao biologists could actually observe embryos and watch a series of progressive steps. Epigenesis eventually displaced preformation as the favored explanation.
The Spemann-Mangold Experiments
Further progress came in fits and starts, occasioned by important events that seem deceptively simple in hindsight. The Spemann-Mangold experiments are an important example that set embrylogy on a truly modern path.
Hans Spemann (27 Jun 1869 — 9 Sep 1941), a German scientist, was awarded the Nobel Prize in Physiology or Medicine in 1935 for his discovery of the effect now known as e
One Controller of Cell Movement Discovered; More To Come?
TS-Si News Service
Saturday, 21 June 2008
Baltimore, MD, USA. Patterns abound in nature: butterfly wings, seashell spirals, zebras stripes. Human genitals. These are all examples of patterns in nature. Pattern formation is a puzzle for both biologists and mathematicians. How does a single fertilized egg yield such delicate designs? How does a pattern emerge out of no pattern?
Using computer models and live cells, researchers at Johns Hopkins University have discovered a specific pattern that can direct cell movement and may help us understand cell movement [N1, N2]. This study was published in Developmental Cell [N3].

Feedback Inhibition of JAK/STAT Signaling by Apontic Is Required to Limit an Invasive Cell Population. Michelle Starz-Gaiano, Mariana Melani, Xiaobo Wang, Hans Meinhardt, and Denise J. Montell. Developmental Cell 2008 14(6): 726-738.

There is considerable science devoted to pattern formation. It deals with the visible and statistically orderly outcomes of self-organization and the common principles behind similar patterns. In developmental biology, pattern formation describes the mechanism by which initially equivalent cells in developing tissue assume complex
So Biometric: Clocking You By The Way You Walk
TS-Si News Service
Thursday, 12 June 2008
Mysuru, Karnataka, India. Technologies that measure and analyze human physical and behavioral characteristics are big when machines have to figure out who you are on behalf of their human creators. There is ample precedent: we all cope with encountering new people and try to understand who you are, really.
The emerging field of biometrics typically analyzes physical and behavioral characteristics. The physical can include DNA databases, facial patterns, fingerprints, hand measurements, iris recognition, and retinal scans. Examples of mostly behavioral characteristics include signature and typing patterns.

Comprehensive framework to gait recognition. Nandini C. and Ravi Kumar, C.N. (2008). International Journal of Biometrics 1(1) 129 - 137. doi: 10.1504 / IJBM.2008.018667 [ Download PDF ]

But at first encounter, others view us by obvious externals, often by the way we walk (our gait). A team of researchers in India have been working on an expanded form of biometrics that could allow law enforcement agencies and airport security to recognize suspects based on their characteristic gait. The team has revealed details of a comprehensi
Understanding How Individual Cells Exchange Information
TS-Si News Service
Friday, 06 June 2008
Nottingham, UK. For an organism to develop and function, the individual cells must exchange information, or communicate, with each other. Is it possible to learn their language and actually talk to the cells? Yes. In cell biology, a vesicle is a small, membrane-bounded sac. Vesicles store, transport, or digest cellular products and waste. They are a basic tool of the cell for organizing metabolism, transport, enzyme storage, as well as being chemical reaction chambers.
Scientists at the University of Nottingham (UK) used sugar groups on the vesicle surface to enable the first conversation between bacterial cells and artificial polymer vesicles. The vesicles subsequently transfer information to the cells — in the form of dye molecules.

Sweet Talking Double Hydrophilic Block Copolymer Vesicles. Cameron Alexander. Angewandte Chemie International Edition 2008 47(26): 4847–4850. doi: 10.1002 / anie.200801098. No abstract. [ Supporting Info PDF ]

Complex structures made of many sugar components on the surfaces of cells are the “language” used for processes such as cell recognition, for example, in the differentiation of tissues or the ident
TS-Si Op-Ed Pages
 

Body Image, Women, And Facial Feminization Surgery

Full Facial Feminization (FFS)
Springfield, VA, USA. Society (the women and men around us) has always been more comfortable if its members fall within certain known, established patterns: this is how we dress, this is what we say, this is...

 
TS-Si Science Access
 

Brain Before Body: The Spemann-Mangold Experiments

Brain Before Body
Washington, DC, USA. Science shows that the human brain and central nervous system form before the remaining portions of our overall body plan. This is a central insight and the province of developmental biology, particularly embryology, which deals with the development of organs and other anatomical structures...

 
TS-Si Medicine
 

Research Shows Aging Brain Brings Benefit Of Mature Perspective

Research Shows Aging Brain Brings Benefit Of Mature Perspective.
Edmunton, Alberta, Canada. Does emotional wisdom come with age? Researchers identified brain patterns that help healthy people over the age of 60 regulate and control emotion better than younger counterparts. Two brain regions increased activity when...

 
TS-Si Policy Review
 

Worth Noting: Washington State Dems Sing A Different Tune

License Plate WTF
Washington, DC, USA. Criticism of the Washington state Democratic Party for an attack ad that linked an Italian-American politician to fictional organized crime. The Pennsylvania Senate ponders expansion of bathroom access to people with bowel disorders. North Carolina's motor vehicle department embarrassed by a sample license plate on its...

TS-Si Society
 

US State Workers Give Thanks For Thursday

Exhausting work week.
Washington, DC, USA. As fuel and energy costs continue to soar to record highs, a growing number of states are offering more of their public employees compressed workweeks to hold down states’ energy spending and give long-distance commuters some relief from paying high gas prices.
 
 
Utah Gov. Jon Huntsman...


Science Enterprise
Check Your Brain: The Microrobotic Construction Crew Cometh
Biotechnology: Public Attitudes On Stem Cell Research
TS-Si News Service
Thursday, 15 May 2008
Where Will Feeling Machines Get Their Emotions? From Us?
TS-Si News Service
Thursday, 10 April 2008
Genetics and the Genome
The Evolution And Significance Of Imprinted Genes
TS-Si News Service
Tuesday, 24 June 2008
Sexual Dimorphism Signatures In The Brains Of Humans And Other Primates
New Technique Targets Specific Gene Inactivation In Embryo
Neuroscience
Brain Mapping Initiative Reaches Core Of Human Brain
TS-Si News Service
Tuesday, 01 July 2008
Complex Synapses Drive Evolution Of The Human Brain
TS-Si News Service
Monday, 30 June 2008
Isolating Comparable Brain Details In Straight Women And Gay Men
 
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In a time to come, people born transsexual shall shake the conscience of our nation.
 

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DSM V & Beyond

DSM-V: Annotated List Of TS-Si.org Articles. Our continuing update of articles on the coming DSM revisions.

Finding Our Way

 
Richard Smith, Editor-in-Chief, introduces Cases Journal. Dr. Smith urges all physicians to submit their case reports to the new open access Cases Journal, which publishes case reports from any area of healthcare.
 
Cases Journal will publish any case report that is understandable, ethical, authentic, and includes all essential information. A more selective companion, the Journal of Medical Case Reports, publishes original and interesting case reports that contribute significantly to medical knowledge. Article submissions are subject to potential publication by either journal. All reports will be entered in a common and open access database.
 
Video courtesy of BioMed Central.
Time 00:01:35.
 
TS-Si articles of related interest:
 
 
• Dr. Richard Smith: Why Do We Need Cases Journal?
 
• Dr. Richard Smith: The Policies Of Cases Journal
 
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