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TS-Si News Service
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Monday, 09 June 2008
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Malaga, Andalucia, Spain. There has been relatively little systematic study of the effects of long-term cross-sex hormone therapy in male-to-female (M2F) and female-to-male (F2M) transsexuals [cf. sidebar]. Now, this is beginning to change. A research team from Hospital Regional Universitario Carlos Haya [N1] studied changes in the serum uric acid (urate) levels. Uric acid, an organic compound, is produced in large quantities by the normal human metabolism.
Ordinarily, people can have elevated levels of uric acid for variety of hereditary or dietary reasons. Any changes in may be an independent mortality factor of Coronary Heart Disease (CHD), cytokines, and various inflammatory markers. Cytokines are a general category of signalling proteins and glycoproteins, critical to the functioning of both innate and adaptive immune responses. Cellular communication depends on them , along with hormones and neurotransmitters.
Effect of Long-Term Administration of Cross-Sex Hormone Therapy on Serum and Urinary Uric Acid in Transsexual Persons. R. Yahyaoui, I. Esteva, J. J. Haro-Mora, M. C. Almaraz, S. Morcillo, G. Rojo-Martínez, J. Martínez, J. M. Gómez-Zumaquero, I. González, V. Hernando and F. Soriguer. Journal of Clinical Endocrinology & Metabolism 93(6) 2230-2233. doi: 10.1210 / jc.2007-2467.
The basis of this study, and a few others like it, is an analysis of the serum chemistry and possble health effects. Blood serum is derived from blood plasma [cf. sidebar] after the removal of blood cells, clotting factors, and other materials. The study of uric acid serum levels produced findings of general interest that were published in The Journal of Clinical Endocrinology & Metabolism.
Serum Uric Acid
Blood
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Sharon Gaughan
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Monday, 19 May 2008
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New Haven, CT, USA. The naturally occurring female sex hormone estradiol plays an important role in maintaining skeletal health by balancing the ongoing processes of bone resorption and bone formation that normally occur throughout life.
Restoring estrogen levels after menopause helps to mitigate some of the more harmful side effects of hormone loss that generally occur during aging.
Researchers have now discovered that cells on their way to forming bone also produce an estrogen-like substance that mimics estradiol. Researchers hope such a molecule might provide some of the benefits but, hopefully, not the health risk of traditional hormonal therapies for menopause and bone loss.
Expression of an estrogen receptor agonist in differentiating osteoblast cultures. Thomas L. McCarthy, Mary E. Clough, Caren M. Gundberg, and Michael Centrella. PNAS 2008 105(19):7022-7; 10.1073 / pnas.0800085105.
 Researchers isol
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TS-Si News Service
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Sunday, 11 May 2008
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San Francisco, CA, USA. Atrazine, a common weedkiller in the U.S., already suspected of causing sexual abnormalities in frogs and fish, has now been found to alter hormonal signaling in human cells. The herbicide is the second most widely used weedkiller in the U.S., applied to corn and sorghum fields throughout the Midwest and also spread on suburban lawns and gardens. It was banned in Europe after studies linked the chemical to endocrine disruptions in fish and amphibians.
The University of California San Francisco (UCSF) study is the first to identify the full effect of atrazine on human cells. In studies with human placental cells in culture, the UCSF scientists found that atrazine increased the activity of a gene associated with abnormal human birth weight when over-expressed in the placenta. It also targeted a second gene that has been found to be amplified in the uterus of women with unexplained infertility. The findings were published in the journal PLoS One.
The Herbicide Atrazine Activates Endocrine Gene Networks via Non-Steroidal NR5A Nuclear Receptors in Fish and Mammalian Cells. Suzawa M, Ingraham HA. PLoS ONE 3(5): e2117 doi: 1
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TS-Si News Service
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Friday, 25 April 2008
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Chevy Chase, MD, USA. Women born with Harry Benjamin Syndrome (HBS) have not been menopausal. Medical practitioners typically provide treatments founded on research into post-menopausal symptoms. New research on pre-menopausal women has a more nearly direct, if inexact, analogue. The subject is hirsutism, the occurrence of increased and excessive hair growth in females at locations where it is normally minimal or absent. The growth patterns are usually those associated with males.
Clinical assessment of body hair growth in women. Ferriman D and Gallwey JD. Journal of Clinical Endocrinology 1961; 21:1440-1447.
Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. Kathryn A. Martin, R. Jeffrey Chang, David A. Ehrmann, Lourdes Ibanez, Rogerio A. Lobo, Robert L. Rosenfield, Jerry Shapiro, Victor M. Montori, and Brian A. Swiglo. J. Clin. |
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Springfield, VA, USA. Society (the women and men around us) has always been more comfortable if its members fall within certain known, established patterns: this is how we dress, this is what we say, this is... |
Washington, DC, USA. Science shows that the human brain and central nervous system form before the remaining portions of our overall body plan. This is a central insight and the province of developmental biology, particularly embryology, which deals with the development of organs and other anatomical structures... |
Edmunton, Alberta, Canada. Does emotional wisdom come with age? Researchers identified brain patterns that help healthy people over the age of 60 regulate and control emotion better than younger counterparts. Two brain regions increased activity when... |
Washington, DC, USA. Criticism of the Washington state Democratic Party for an attack ad that linked an Italian-American politician to fictional organized crime. The Pennsylvania Senate ponders expansion of bathroom access to people with bowel disorders. North Carolina's motor vehicle department embarrassed by a sample license plate on its... |
Washington, DC, USA. As fuel and energy costs continue to soar to record highs, a growing number of states are offering more of their public employees compressed workweeks to hold down states’ energy spending and give long-distance commuters some relief from paying high gas prices.
Utah Gov. Jon Huntsman... |
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Dr. Richard Smith
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Thursday, 22 May 2008
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Dr. Richard Smith
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Thursday, 22 May 2008
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TS-Si News Service
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Tuesday, 20 May 2008
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TS-Si News Service
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Monday, 23 June 2008
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Sharon Gaughan
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Friday, 20 June 2008
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TS-Si News Service
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Monday, 02 June 2008
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TS-Si News Service
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Friday, 21 March 2008
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TS-Si News Service
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Friday, 14 March 2008
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TS-Si News Service
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Friday, 14 March 2008
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TS-Si News Service
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Wednesday, 25 June 2008
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TS-Si News Service
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Sunday, 01 June 2008
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TS-Si News Service
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Wednesday, 07 May 2008
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TS-Si News Service
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Saturday, 19 April 2008
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TS-Si News Service
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Friday, 11 April 2008
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TS-Si News Service
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Wednesday, 19 March 2008
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TS-Si News Service
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Sunday, 16 March 2008
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TS-Si News Service
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Saturday, 15 March 2008
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So They Say
It is not who is right, but what is right, that is of importance.
Thomas A. Huxley
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Subscribe To The TS-Si Insider
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Finding Our Way
Richard Smith, Editor-in-Chief, introduces Cases Journal. Dr. Smith urges all physicians to submit their case reports to the new open access Cases Journal, which publishes case reports from any area of healthcare.
Cases Journal will publish any case report that is understandable, ethical, authentic, and includes all essential information. A more selective companion, the Journal of Medical Case Reports, publishes original and interesting case reports that contribute significantly to medical knowledge. Article submissions are subject to potential publication by either journal. All reports will be entered in a common and open access database.
Time 00:01:35.
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Copyright © 2005-2008 TS-Si, Inc. • Except where noted, this site is licensed under a Creative Commons Attribution-NoDerivs 2.5 License. • Some rights reserved. • TS-Si is a nonprofit organization dedicated to the acceptance, medical treatment, & legal protection of individuals in the process of correcting the misalignment of their anatomical sex, & supporting their transition into society.