The Human Genome Project (HGP). The HGP identified all of the genes in the human genome and mapped their individual sequencing. Basic work began in 1990 and reached completion in 2005, sparking continuous refinements and new projects. Though the HGP is finished, data analyses will continue for many years.

 

A genome is all the DNA in an organism, including its genes and other materials. Genes carry information for making all the proteins required by all organisms. These proteins determine, among other things, how the organism looks, how well its body metabolizes food or fights infection, and to an extent even how it behaves.

 

DNA is made up of four similar chemicals (called bases and abbreviated A, T, C, and G) that are repeated millions or billions of times throughout a genome. The human genome, for example, has 3 billion pairs of bases. The particular order of As, Ts, Cs, and Gs is extremely important.

 

The order underlies all of life's diversity, even dictating whether an organism is human or another species such as yeast, rice, or fruit fly, all of which have their own genomes and are themselves the focus of genome projects. Because all organisms are related through similarities in DNA sequences, insights gained from nonhuman genomes often lead to new knowledge about human biology.

 

Video: An introduction to the ongoing Human Genome Project, courtesy of the US National Institutes of Health NIH) (18 May 2007). Time: 00:03:33. Creative Commons license: Attribution-NonCommercial-NoDerivs.

 

For more information see the TS-Si.org Genetics / Genome section.

 

DSM-V: Annotated List Of TS-Si.org Articles. Our continuing update of articles on the coming DSM revisions.

 

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